Targeted drug delivery with modified gamma-Cyclodextrin nanocarriers and MR-guided focused ultrasound triggering
نویسندگان
چکیده
منابع مشابه
Targeted drug delivery with modified gamma-Cyclodextrin nanocarriers and MR-guided focused ultrasound triggering
Background/introduction NANOPORATION project sets out to explore specific solutions to overcome the current challenges of targeted drug delivery (TDD) to tumours using magnetic resonance imaging guided focused ultrasound (MRgFUS) to cavitate microbubbles (MBs) for increasing cell permeability and to open ‘drug nano-capsules’ for releasing proven active anticancer drugs directly to the tumour si...
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The joining of high-intensity focused ultrasound with high-resolution MR guidance has created a system that can produce tissue destruction deep within solid organs without any invasion. Accurate targeting and thermal mapping are provided by MRI and allow very accurate deposition of energy in tissues that can be altered in response to near real-time thermal imaging produced by MR so that the var...
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In a large number of biological and environmental applications, ultrasound (US)-powered microand nanomotors have attracted considerable attention. However, their applications in biological settings have been limited due to the incompatibility of metallic motors and the lack of precision guiding. Here, we demonstrate that cellulosic polymer nanobubbles (200-800nm) can be propelled, aligned, acce...
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Prostate cancer (PC) is one of the most frequently diagnosed cancers in men. There are a number of treatment options for PC with a different therapeutic approach between USA and Europe. Radical prostatectomy is one of the most used therapies but focal gland therapy is an emerging approach, especially for localized tumors. In this scenario, high intensity focused ultrasound (HIFU) has been incor...
متن کاملSupramolecular cyclodextrin-based drug nanocarriers.
Supramolecular systems formed by the binding of several cyclodextrins (CDs) to polymers or lipids, either via non-covalent or covalent links, open a wide range of possibilities for the delivery of active substances. CDs can perform as multifunctionalizable cores to which very diverse (macro)molecules and drugs can be conjugated. Grafting with amphiphilic molecules can lead to nanoassemblies exh...
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ژورنال
عنوان ژورنال: Journal of Therapeutic Ultrasound
سال: 2015
ISSN: 2050-5736
DOI: 10.1186/2050-5736-3-s1-p79